Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT1 regulates metabolism and leukemogenic potential in CML stem cells

9 Jun 2019

Abstract excerpt

Chronic myeloid leukemia (CML) results from hematopoietic stem cell transformation by the BCR-ABL kinase. Despite the success of BCR-ABL tyrosine kinase inhibitors (TKIs) in treating CML patients, leukemia stem cells (LSCs) resist elimination and persist as a major barrier to cure. Previous studies suggest that overexpression of the sirtuin 1 (SIRT1) deacetylase may contribute to LSC maintenance in CML. Here, by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone Deacetylase Inhibitors Research
Share to PI3K/AKT/mTOR signaling in cancer
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31180336
DOI: 10.1172/jci127080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT1 regulates metabolism and leukemogenic potential in CML stem cellsPMID 31180336Read ↗

Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cellsSemantic proximity Read ↗

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesisSemantic proximity Read ↗

SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid LeukemiaSemantic proximity Read ↗

SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells.Semantic proximity Read ↗

Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicitySemantic proximity Read ↗

Role of SIRT1 in Chemoresistant LeukemiaSemantic proximity Read ↗

SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1 <b>α</b> –Dependent GlycolysisSemantic proximity Read ↗

Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogrammingSemantic proximity Read ↗

Mitochondrial sirtuins: Energy dynamics and cancer metabolismSemantic proximity Read ↗

Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia.Semantic proximity Read ↗

The Role of the Sirtuin Family Histone Deacetylases in Acute Myeloid Leukemia – A Promising Road AheadSemantic proximity Read ↗

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during StressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.