Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

10 Apr 2021

Abstract excerpt

Abstract We discovered that the survival and growth of many primary acute myeloid leukemia (AML) samples and cell lines, but not normal CD34+ cells, are dependent on SIRT5, a lysine deacylase implicated in regulating multiple metabolic pathways. Dependence on SIRT5 is genotype agnostic and extends to RAS- and p53-mutated AML. Results were comparable between SIRT5 knockdown and SIRT5 inhibition using NRD167, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Histone Deacetylase Inhibitors Research
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34027418
DOI: 10.1158/2643-3230.bcd-20-0168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid LeukemiaPMID 34027418Read ↗

SIRT1 regulates metabolism and leukemogenic potential in CML stem cellsSemantic proximity Read ↗

Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicitySemantic proximity Read ↗

Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cellsSemantic proximity Read ↗

NAD metabolism-related genes provide prognostic value and potential therapeutic insights for acute myeloid leukemiaSemantic proximity Read ↗

The Role of the Sirtuin Family Histone Deacetylases in Acute Myeloid Leukemia – A Promising Road AheadSemantic proximity Read ↗

Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid LeukemiaSemantic proximity Read ↗

Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemiaSemantic proximity Read ↗

Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.Semantic proximity Read ↗

Metabolism in acute myeloid leukemia: mechanistic insights and therapeutic targetsSemantic proximity Read ↗

Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function.Semantic proximity Read ↗

Mitochondrial sirtuins: Energy dynamics and cancer metabolismSemantic proximity Read ↗

SIRT5-dependent regulation of ASL controls arginine metabolism and T cell functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.