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Article

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

29 Dec 2011

Abstract excerpt

The tyrosine kinase inhibitor imatinib is highly effective in the treatment of chronic myelogenous leukemia (CML), but primary and acquired resistance of CML cells to the drug offset its efficacy. Molecular mechanisms for resistance of CML to tyrosine kinase inhibitors are not fully understood. In the present study, we show that BCR-ABL activates the expression of the mammalian stress response gene SIRT1 in...

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PMID: 22207735
DOI: 10.1182/blood-2011-06-361691

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