Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1 <b>α</b> –Dependent Glycolysis

19 Dec 2013

Abstract excerpt

Myeloid-derived suppressor cells (MDSC) display an immature phenotype that may assume a classically activated (M1) or alternatively activated phenotype (M2) in tumors. In this study, we investigated metabolic mechanisms underlying the differentiation of MDSCs into M1 or M2 myeloid lineage and their effect on cancer pathophysiology. We found that SIRT1 deficiency in MDSCs directs a specific switch to M1 lineage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine and Purinergic Signaling
Share to Autophagy in Disease and Therapy
Share to Immune cells in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24351289
DOI: 10.1158/0008-5472.can-13-2584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1 <b>α</b> –Dependent GlycolysisPMID 24351289Read ↗

Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogrammingSemantic proximity Read ↗

Energy metabolism drives myeloid-derived suppressor cell differentiation and functions in pathologySemantic proximity Read ↗

SIRT1 regulates metabolism and leukemogenic potential in CML stem cellsSemantic proximity Read ↗

Feedback loop between hypoxia and energy metabolic reprogramming aggravates the radioresistance of cancer cellsSemantic proximity Read ↗

Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cellsSemantic proximity Read ↗

HIF-1 — A BIG CHAPTER IN THE CANCER TALESemantic proximity Read ↗

Mechanisms of T‑cell metabolic reprogramming in the microenvironment of acute myeloid leukemia and its therapeutic potential (Review)Semantic proximity Read ↗

Untuning the tumor metabolic machine: HIF-α: pro- and antitumorigenic?Semantic proximity Read ↗

SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid LeukemiaSemantic proximity Read ↗

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and CarcinogenesisSemantic proximity Read ↗

HIF1α-glycolysis engages activation-induced cell death to drive IFN-γ induction in hypoxic T cellsSemantic proximity Read ↗

Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.