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Article

Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells

7 Jun 2015

Abstract excerpt

PURPOSE OF REVIEW: Recent studies have enhanced our understanding of the role of the SIRT1 deacetylase in regulation of normal hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs), and its importance in regulating autophagy and epigenetic reprogramming in response to metabolic alterations. RECENT FINDINGS: Studies employing conditional deletion mouse models indicate an important role of SIRT1 in...

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PMID: 26049753
DOI: 10.1097/moh.0000000000000152

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