Article
Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia.
Communications biology - 28 Apr 2022
Wang Zhiqiang, Zhang Chunxiao, Warden Charles David, Liu Zheng, Yuan Yate-Ching, Guo Chao, Wang Charles, Wang Jinhui, Wu Xiwei, Ermel Richard, Vonderfecht Steven L, Wang Xiuli, Brown Christine, Forman Stephen, Yang Yaling, James You M, Chen WenYong
Abstract excerpt
Aging of hematopoietic stem cells (HSCs) is linked to various blood disorders and malignancies. SIRT1 has been implicated in healthy aging, but its role in HSC aging is poorly understood. Surprisingly, we found that Sirt1 knockout improved the maintenance of quiescence of aging HSCs and their functionality as well as mouse survival in serial bone marrow transplantation (BMT) recipients. The majority of secondary...
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