The Role of the Sirtuin Family Histone Deacetylases in Acute Myeloid Leukemia – A Promising Road Ahead

Abstract excerpt

Acute myeloid leukemia (AML) corresponds to a heterogeneous group of clonal hematopoietic diseases, which are characterized by uncontrolled proliferation of malignant transformed myeloid precursors and their inability to differentiate into mature blood cells. The prognosis of AML depends on many variables, including the genetic features of the disease. Treatment outcomes, despite the introduction of new targeted t...

Topics

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• Autophagy in Disease and Therapy
• Calcium signaling and nucleotide metabolism
• Genomics, phytochemicals, and oxidative stress
• Histone Deacetylase Inhibitors Research
• PARP inhibition in cancer therapy
• Sirtuins and Resveratrol in Medicine
• Tea Polyphenols and Effects

Identifiers and source

Literature Corpus work

ed15a783-8641-5a0c-b893-775e130572d2

DOI

10.20944/preprints202502.1175.v1