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Article

Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes

10 Jun 2019

Abstract excerpt

Cancer cells become immortalized through telomere maintenance mechanisms, such as telomerase reverse transcriptase (TERT) activation. In addition to maintaining telomere length, TERT activates manifold cell survival signaling pathways. However, telomerase-associated gene signatures in cancer remain elusive. We performed a systematic analysis of TERT high (TERT high ) and low (TERT low ) cancers using...

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PMID: 31179925
DOI: 10.1186/s12943-019-1035-x

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