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Article

The devil is in the details: comparison between COP9 signalosome (CSN) and the LID of the 26S proteasome.

Current genetics - 1 Feb 2016

Meister Cindy, Gulko Miriam Kolog, Köhler Anna M, Braus Gerhard H

Abstract excerpt

The COP9 signalosome (CSN) and the proteasomal LID are conserved macromolecular complexes composed of at least eight subunits with molecular weights of approximately 350 kDa. CSN and LID are part of the ubiquitin–proteasome pathway and cleave isopeptide linkages of lysine side chains on target proteins. CSN cleaves the isopeptide bond of ubiquitin-like protein Nedd8 from cullins, whereas the LID cleaves ubiquitin...

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PMID: 26497135
DOI: 10.1007/s00294-015-0525-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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