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Article

Rpn5 is a conserved proteasome subunit and required for proper proteasome localization and assembly.

The Journal of biological chemistry - 15 Aug 2003

Yen Hsueh-Chi S, Espiritu Christine, Chang Eric C

Abstract excerpt

Proper function of the 26 S proteasome requires assembly of the regulatory complex, which is composed of the lid and base subcomplexes. We characterized Rpn5, a lid subunit, in fission yeast. We show that Rpn5 associates with the proteasome rpn5. Deletion (rpn5Delta) exacerbates the growth defects in proteasome mutants, leading to mitotic abnormalities, which correlate with accumulation of polyubiquitinated...

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Identifiers

PMID: 12783882
DOI: 10.1074/jbc.M302093200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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