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Article

Chaperone-mediated pathway of proteasome regulatory particle assembly.

Nature - 11 Jun 2009

Roelofs Jeroen, Park Soyeon, Haas Wilhelm, Tian Geng, McAllister Fiona E, Huo Ying, Lee Byung-Hoon, Zhang Fan, Shi Yigong, Gygi Steven P, Finley Daniel

Abstract excerpt

The proteasome is a protease that controls diverse processes in eukaryotic cells. Its regulatory particle (RP) initiates the degradation of ubiquitin-protein conjugates by unfolding the substrate and translocating it into the proteasome core particle (CP) to be degraded. The RP has 19 subunits, and their pathway of assembly is not understood. Here we show that in the yeast Saccharomyces cerevisiae three proteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19412159
DOI: 10.1038/nature08063
PMCID: PMC2727592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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