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Article

Incorporation of the Rpn12 subunit couples completion of proteasome regulatory particle lid assembly to lid-base joining.

Molecular cell - 23 Dec 2011

Tomko Robert J, Hochstrasser Mark

Abstract excerpt

The 26S proteasome, the central eukaryotic protease, comprises a core particle capped by a 19S regulatory particle (RP). The RP is divisible into base and lid subcomplexes. Lid biogenesis and incorporation into the RP remain poorly understood. We report several lid intermediates, including the free Rpn12 subunit and a lid particle (LP) containing the remaining eight subunits, LP2. Rpn12 binds LP2 in vitro, and...

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Identifiers

PMID: 22195964
DOI: 10.1016/j.molcel.2011.11.020
PMCID: PMC3251515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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