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Article

beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint.

The EMBO journal - 2 May 2007

Li Xia, Kusmierczyk Andrew R, Wong Peter, Emili Andrew, Hochstrasser Mark

Abstract excerpt

Proteasomes are responsible for most intracellular protein degradation in eukaryotes. The 20S proteasome comprises a dyad-symmetric stack of four heptameric rings made from 14 distinct subunits. How it assembles is not understood. Most subunits in the central pair of beta-subunit rings are synthesized in precursor form. Normally, the beta5 (Doa3) propeptide is essential for yeast proteasome biogenesis, but...

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Identifiers

PMID: 17431397
DOI: 10.1038/sj.emboj.7601681
PMCID: PMC1864979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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