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Article

Restored immune cell functions upon clearance of senescence in the irradiated splenic environment

31 May 2019

Abstract excerpt

Abstract Some studies show eliminating senescent cells rejuvenate aged mice and attenuate deleterious effects of chemotherapy. Nevertheless, it remains unclear whether senescence affects immune cell function. We provide evidence that exposure of mice to ionizing radiation (IR) promotes the senescent‐associated secretory phenotype (SASP) and expression of p16 INK4a in splenic cell populations. We observe splenic T...

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PMID: 31148373
DOI: 10.1111/acel.12971

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