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Article

p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.

Aging - 2 Aug 2017

Hall Brandon M, Balan Vitaly, Gleiberman Anatoli S, Strom Evguenia, Krasnov Peter, Virtuoso Lauren P, Rydkina Elena, Vujcic Slavoljub, Balan Karina, Gitlin Ilya I, Leonova Katerina I, Consiglio Camila R, Gollnick Sandra O, Chernova Olga B, Gudkov Andrei V

Abstract excerpt

Constitutive p16Ink4a expression, along with senescence-associated β-galactosidase (SAβG), are commonly accepted biomarkers of senescent cells (SCs). Recent reports attributed improvement of the healthspan of aged mice following p16Ink4a-positive cell killing to the eradication of accumulated SCs. However, detection of p16Ink4a/SAβG-positive macrophages in the adipose tissue of old mice and in the peritoneal...

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Identifiers

PMID: 28768895
DOI: 10.18632/aging.101268
PMCID: PMC5611982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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