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Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche

14 Oct 2020

Abstract excerpt

Radiotherapy for head and neck cancer is associated with impairment of salivary gland function and consequent xerostomia, which has a devastating effect on the quality of life of the patients. The mechanism of radiation-induced salivary gland damage is not completely understood. Cellular senescence is a permanent state of cell cycle arrest accompanied by a secretory phenotype which contributes to inflammation and...

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Share to Mesenchymal stem cell research
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PMID: 33056980
DOI: 10.1038/s41419-020-03074-9

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