Article

Elimination of senescent cells with senolytic host-directed therapy reduces tuberculosis progression in mice

2025-03-28

Abstract excerpt

By eliciting lung necrosis, which enhances aerosol transmission, Mycobacterium tuberculosis ( Mtb ) sustains its long-term survival as a human pathogen. In studying the human-like necrotic granuloma lesions characteristic of Mtb -infected B6.Sst1S mice, we found that lung myeloid cells display elevated senescence markers: cell cycle arrest proteins p21 and p16, the DNA damage marker γH2A.X, senescence-associat...

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Literature Corpus work: 0995ec3f-e38b-5545-9fd5-3ec9ef2e0ed8
DOI: 10.1101/2025.03.28.645957

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