Article

Parkinson’s disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and PARP1 hyperactive signaling

2026-03-01

Abstract excerpt

<h4>ABSTRACT</h4> LRRK2 mutations are the most common cause of autosomal-dominant Parkinson’s disease (PD), with G2019S linked to both familial and sporadic PD. Although LRRK2-mediated mitochondrial DNA damage is implicated in PD, the contribution of nuclear DNA damage is less understood. Using CRISPR/Cas9-generated LRRK2 G2019S/G2019S knock-in cells, we discovered increased sensitivity to oxidative and alkylati...

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Literature Corpus work: 3b95445d-2bc0-5069-9793-d845c2e2827a
DOI: 10.64898/2026.02.27.708379

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