Article
LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction.
Neurobiology of disease - 1 Feb 2014
Sanders Laurie H, Laganière Josée, Cooper Oliver, Mak Sally K, Vu B Joseph, Huang Y Anne, Paschon David E, Vangipuram Malini, Sundararajan Ramya, Urnov Fyodor D, Langston J William, Gregory Philip D, Zhang H Steve, Greenamyre J Timothy, Isacson Ole, Schüle Birgitt
Abstract excerpt
Parkinson's disease associated mutations in leucine rich repeat kinase 2 (LRRK2) impair mitochondrial function and increase the vulnerability of induced pluripotent stem cell (iPSC)-derived neural cells from patients to oxidative stress. Since mitochondrial DNA (mtDNA) damage can compromise mitochondrial function, we examined whether LRRK2 mutations can induce damage to the mitochondrial genome. We found greater...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.