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Article

Higher urate in LRRK2 mutation carriers resistant to Parkinson disease

14 Feb 2019

Abstract excerpt

OBJECTIVE: LRRK2 mutations, the most common genetic cause of Parkinson disease (PD), display incomplete penetrance, indicating the importance of other genetic and environmental influences on disease pathogenesis in LRRK2 mutation carriers. The present study investigates whether urate, an antioxidant, Nrf2 activator, and inverse risk factor for idiopathic PD, is one such candidate biomarker of PD risk modulation...

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Share to Genomics, phytochemicals, and oxidative stress
Share to Gout, Hyperuricemia, Uric Acid
Share to Parkinson's Disease Mechanisms and Treatments

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PMID: 30761591
DOI: 10.1002/ana.25436

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