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Article

EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidation

14 May 2019

Abstract excerpt

genes. Whereas the levels of 5hmC, 5fC, and 5caC increased, 5mC levels decreased in the mutant maternal pronuclei. H3K9me3-rich rings around the nucleolar-like bodies retained 5mC in the maternal mutant zygotes, suggesting that the pericentromeric heterochromatin regions are protected from DNA demethylation independently of EHMT2 and SETDB1. We observed that the maternal pronuclei expanded in size in the mutant...

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PMID: 31088968
DOI: 10.1073/pnas.1819946116

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