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Article

DNA methylation dynamics in mouse preimplantation embryos revealed by mass spectrometry

11 Jan 2016

Abstract excerpt

Following fertilization in mammals, paternal genomic 5-methyl-2'-deoxycytidine (5 mC) content is thought to decrease via oxidation to 5-hydroxymethyl-2'-deoxycytidine (5 hmC). This reciprocal model of demethylation and hydroxymethylation is inferred from indirect, non-quantitative methods. We here report direct quantification of genomic 5 mC and 5 hmC in mouse embryos by small scale liquid chromatographic tandem...

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PMID: 26750605
DOI: 10.1038/srep19134

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