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Catalytic inhibition of H3K9me2 writers disturbs epigenetic marks during bovine nuclear reprogramming

13 Jul 2020

Abstract excerpt

Orchestrated events, including extensive changes in epigenetic marks, allow a somatic nucleus to become totipotent after transfer into an oocyte, a process termed nuclear reprogramming. Recently, several strategies have been applied in order to improve reprogramming efficiency, mainly focused on removing repressive epigenetic marks such as histone methylation from the somatic nucleus. Herein we used the specific...

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PMID: 32661262
DOI: 10.1038/s41598-020-67733-9

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