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Article

Chromosome hydroxymethylation patterns in human zygotes and cleavage-stage embryos

12 Dec 2014

Abstract excerpt

We report the sequential changes in 5-hydroxymethylcytosine (5hmC) patterns in the genome of human preimplantation embryos during DNA methylation reprogramming. We have studied chromosome hydroxymethylation and methylation patterns in triploid zygotes and blastomeres of cleavage-stage embryos. Using indirect immunofluorescence, we have analyzed the localization of 5hmC and its co-distribution with...

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PMID: 25504867
DOI: 10.1530/rep-14-0343

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