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Article

Evolution and Genetic Diversity of thek13Gene Associated with Artemisinin Delayed Parasite Clearance in Plasmodium falciparum

13 May 2019

Abstract excerpt

Mutations in the Plasmodium falciparum k13(Pfk13) gene are linked to delayed parasite clearance in response to artemisinin-based combination therapies (ACTs) in Southeast Asia. To explore the evolutionary rate and constraints acting on this gene,k13orthologs from species sharing a recent common ancestor with P. falciparum and Plasmodium vivax were analyzed.

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PMID: 31085516
DOI: 10.1128/aac.02550-18

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