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Article

Novel Plasmodium falciparum k13 gene polymorphisms from Kisii County, Kenya during an era of artemisinin-based combination therapy deployment.

Malaria journal - 9 Mar 2023

Maniga Josephat Nyabayo, Samuel Mong'are, John Odda, Rael Masai, Muchiri Jacqueline Njeri, Bwogo Pacifica, Martin Odoki, Sankarapandian Vidya, Wilberforce Mfitundinda, Albert Ochweri, Onkoba Sarah Kemuma, Adebayo Ismail Abiola, Adeyemo Rasheed Omotayo, Akinola Saheed Adekunle

Abstract excerpt

BACKGROUND: Currently, chemotherapy stands out as the major malaria intervention strategy, however, anti-malarial resistance may hamper global elimination programs. Artemisinin-based combination therapy (ACT) stands as the drug of choice for the treatment of Plasmodium falciparum malaria. Plasmodium falciparum kelch13 gene mutations are associated with artemisinin resistance. Thus, this study was aimed at...

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Identifiers

PMID: 36894982
DOI: 10.1186/s12936-023-04517-2
PMCID: PMC9996564

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