Article
A Single Mutation in K13 Predominates in Southern China and Is Associated With Delayed Clearance of Plasmodium falciparum Following Artemisinin Treatment.
The Journal of infectious diseases - 15 Nov 2015
Huang Fang, Takala-Harrison Shannon, Jacob Christopher G, Liu Hui, Sun Xiaodong, Yang Henglin, Nyunt Myaing M, Adams Matthew, Zhou Shuisen, Xia Zhigui, Ringwald Pascal, Bustos Maria Dorina, Tang Linhua, Plowe Christopher V
Abstract excerpt
BACKGROUND: Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and poses a threat to malaria control and elimination. Mutations in a P. falciparum gene encoding a kelch protein on chromosome 13 have been associated with delayed parasite clearance following artemisinin treatment elsewhere in the region, but not yet in China. METHODS: Therapeutic efficacy studies of artesunate and...
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