Article
DNA-reactive B cells in lupus.
Current opinion in immunology - 1 Dec 2016
Suurmond Jolien, Calise Justine, Malkiel Susan, Diamond Betty
Abstract excerpt
IgG anti-DNA antibodies are both diagnostic and pathogenic for systemic lupus erythematosus (SLE). They contribute to tissue inflammation through direct tissue binding and to systemic inflammation through activation of Toll-like receptors by nucleic acid-containing immune complexes. IgG DNA-reactive antibodies originate when B cell tolerance mechanisms are impaired. The heterogeneous immune perturbations in SLE...
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