Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus.

Frontiers in immunology - 1 Jan 2018

Malkiel Susan, Barlev Ashley N, Atisha-Fregoso Yemil, Suurmond Jolien, Diamond Betty

Abstract excerpt

Plasma cells (PCs) are responsible for the production of protective antibodies against infectious agents but they also produce pathogenic antibodies in autoimmune diseases, such as systemic lupus erythematosus (SLE). Traditionally, high affinity IgG autoantibodies are thought to arise through germinal center (GC) responses. However, class switching and somatic hypermutation can occur in extrafollicular (EF)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Germinal Center
Share to Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Targeted Therapy

Share to Plasma Cells

Share to Receptor Cross-Talk

Share to Receptors, Antigen, B-Cell

Share to Toll-Like Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 29556239
DOI: 10.3389/fimmu.2018.00427
PMCID: PMC5845388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus.PMID 29556239Read ↗

CD154–CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosusSemantic proximity Read ↗

Immunopathogenesis of systemic lupus erythematosus: An update.Semantic proximity Read ↗

Monogenic lupus: insights into disease pathogenesis and therapeutic opportunitiesSemantic proximity Read ↗

The Plasma Cell Signature in Autoimmune DiseaseSemantic proximity Read ↗

Monogenic systemic lupus erythematosus: insights in pathophysiology.Semantic proximity Read ↗

A compass that points to lupus: genetic studies on type I interferon pathway.Semantic proximity Read ↗

Plasmablasts With a Mucosal Phenotype Contribute to Plasmacytosis in Systemic Lupus Erythematosus.Semantic proximity Read ↗

Plasma cells in immunopathology: concepts and therapeutic strategies.Semantic proximity Read ↗

Variant-to-function mapping in lupus links <i>IL12A</i> to the expansion of disease-associated B cells with a cytotoxic programSemantic proximity Read ↗

Patterns of ANA+ B cells for SLE patient stratificationSemantic proximity Read ↗

Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosusSemantic proximity Read ↗

B cells in systemic lupus erythematosusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.