Article
Cancer Neoepitopes for Immunotherapy: Discordance Between Tumor-Infiltrating T Cell Reactivity and Tumor MHC Peptidome Display.
Frontiers in immunology - 1 Jan 2019
Wickström Stina L, Lövgren Tanja, Volkmar Michael, Reinhold Bruce, Duke-Cohan Jonathan S, Hartmann Laura, Rebmann Janina, Mueller Anja, Melief Jeroen, Maas Roeltje, Ligtenberg Maarten, Hansson Johan, Offringa Rienk, Seliger Barbara, Poschke Isabel, Reinherz Ellis L, Kiessling Rolf
Abstract excerpt
Tumor-infiltrating lymphocytes (TIL) are considered enriched for T cells recognizing shared tumor antigens or mutation-derived neoepitopes. We performed exome sequencing and HLA-A*02:01 epitope prediction from tumor cell lines from two HLA-A2-positive melanoma patients whose TIL displayed strong tumor reactivity. The potential neoepitopes were screened for recognition using autologous TIL by immunological assays...
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