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Article

Proteogenomic Analysis Unveils the HLA Class I-Presented Immunopeptidome in Melanoma and EGFR-Mutant Lung Adenocarcinoma.

Molecular & cellular proteomics : MCP - 1 Jan 2021

Qi Yue A, Maity Tapan K, Cultraro Constance M, Misra Vikram, Zhang Xu, Ade Catherine, Gao Shaojian, Milewski David, Nguyen Khoa D, Ebrahimabadi Mohammad H, Hanada Ken-Ichi, Khan Javed, Sahinalp Cenk, Yang James C, Guha Udayan

Abstract excerpt

Immune checkpoint inhibitors and adoptive lymphocyte transfer-based therapies have shown great therapeutic potential in cancers with high tumor mutational burden (TMB), such as melanoma, but not in cancers with low TMB, such as mutant epidermal growth factor receptor (EGFR)-driven lung adenocarcinoma. Precision immunotherapy is an unmet need for most cancers, particularly for cancers that respond inadequately to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34391887
DOI: 10.1016/j.mcpro.2021.100136
PMCID: PMC8724932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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