Article
Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2006
Feng Yuanyi, Chen Ming Hui, Moskowitz Ivan P, Mendonza Ashley M, Vidali Luis, Nakamura Fumihiko, Kwiatkowski David J, Walsh Christopher A
Abstract excerpt
Mutations in the human Filamin A (FLNA) gene disrupt neuronal migration to the cerebral cortex and cause cardiovascular defects. Complete loss of Flna in mice results in embryonic lethality with severe cardiac structural defects involving ventricles, atria, and outflow tracts, as well as widespread aberrant vascular patterning. Despite these widespread developmental defects, migration and motility of many cell...
Topics
- Animals
- Brain
- Cell Communication
- Cell Movement
- Cells, Cultured
- Contractile Proteins
- Embryo, Mammalian
- Endothelial Cells
- Filamins
- Heart
- Heart Failure
- Mice
- Mice, Transgenic