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Article

Smooth muscle filamin A is a major determinant of conduit artery structure and function at the adult stage.

Pflugers Archiv : European journal of physiology - 1 Jul 2016

Retailleau Kevin, Arhatte Malika, Demolombe Sophie, Jodar Martine, Baudrie Véronique, Offermanns Stefan, Feng Yuanyi, Patel Amanda, Honoré Eric, Duprat Fabrice

Abstract excerpt

Human mutations in the X-linked FLNA gene are associated with a remarkably diverse phenotype, including severe arterial morphological anomalies. However, the role for filamin A (FlnA) in vascular cells remains partially understood. We used a smooth muscle (sm)-specific conditional mouse model to delete FlnA at the adult stage, thus avoiding the developmental effects of the knock-out. Inactivation of smFlnA in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27023351
DOI: 10.1007/s00424-016-1813-x

Genes

FLNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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