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Article

Filamin A regulates monocyte migration through Rho small GTPases during osteoclastogenesis

24 Nov 2009

Abstract excerpt

Osteoclastogenesis (OCG) results from the fusion of monocytes after stimulation with macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL). Migration of monocytes into close proximity precedes critical fusion events that are required for osteoclast formation. Cellular migration requires leading-edge actin cytoskeleton assembly that drives cellular locomotion. Filamin A...

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PMID: 19929439
DOI: 10.1359/jbmr.091114

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