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Article

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion.

The Journal of experimental medicine - 25 Oct 2010

Xu Yingjie, Bismar Tarek A, Su Jie, Xu Bin, Kristiansen Glen, Varga Zsuzsanna, Teng Lianghong, Ingber Donald E, Mammoto Akiko, Kumar Rakesh, Alaoui-Jamali Moulay A

Abstract excerpt

The actin cross-linking protein filamin A (FLNa) functions as a scaffolding protein and couples cell cytoskeleton to extracellular matrix and integrin receptor signaling. In this study, we report that FLNa suppresses invasion of breast cancer cells and regulates focal adhesion (FA) turnover. Two large progression tissue microarrays from breast cancer patients revealed a significant decrease of FLNa levels in...

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Identifiers

PMID: 20937704
DOI: 10.1084/jem.20100433
PMCID: PMC2964581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion.PMID 20937704Read ↗

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