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Article

Filamin C is Essential for mammalian myocardial integrity

27 Jan 2023

Abstract excerpt

FLNC, encoding filamin C, is one of the most mutated genes in dilated and hypertrophic cardiomyopathy. However, the precise role of filamin C in mammalian heart remains unclear. In this study, we demonstrated Flnc global (FlncgKO) and cardiomyocyte-specific knockout (FlnccKO) mice died in utero from severely ruptured ventricular myocardium, indicating filamin C is required to maintain the structural integrity of...

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PMID: 36706168
DOI: 10.1371/journal.pgen.1010630

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