Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophage recruitment is a hallmark of non-syndromic myxomatous mitral valve disease.

Cardiovascular research - 14 Aug 2026

Le Vely Benjamin, Delwarde Constance, Toquet Claire, Aumond Pascal, Blank-Stein Nelli, Charon Emilie, Rémy Séverine, Anegon Ignacio, Myasoedova Veronika A, Valerio Vincenza, Poggio Paolo, Le Scouarnec Solena, Schott Jean-Jacques, Le Tourneau Thierry, Merot Jean, Mass Elvira, Capoulade Romain

Abstract excerpt

AIMS: Myxomatous mitral valve disease (MMVD) is a progressive cardiac disease characterized by extracellular matrix remodelling, leaflet thickening, and proteoglycan accumulation. Despite its significant contribution to cardiovascular morbidity and mortality, the underlying pathophysiological mechanisms involved in its development and progression remain unclear. Recent investigations have revealed a genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Filamins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knock-In Techniques

Share to Macrophage Activation

Share to Macrophages

Share to Mitral Valve

Share to Mitral Valve Prolapse

Share to Signal Transduction

Source

Identifiers

PMID: 42334384
DOI: 10.1093/cvr/cvag132

Genes

FLNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophage recruitment is a hallmark of non-syndromic myxomatous mitral valve disease.PMID 42334384Read ↗

Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model.Semantic proximity Read ↗

Nonbiased Molecular Screening Identifies Novel Molecular Regulators of Fibrogenic and Proliferative Signaling in Myxomatous Mitral Valve DiseaseSemantic proximity Read ↗

Cross-Species Multi-Omics Profiling Identifies Conserved Activated Valvular Interstitial Cell Population Driving Myxomatous Mitral Valve DegenerationSemantic proximity Read ↗

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targetsSemantic proximity Read ↗

Mitral valve disease in Marfan syndrome and related disorders.Semantic proximity Read ↗

Emerging pathogenic mechanisms in human myxomatous mitral valve: lessons from past and novel data.Semantic proximity Read ↗

Macrophage Transitions in Heart Valve Development and Myxomatous Valve Disease.Semantic proximity Read ↗

Genetics of syndromic and non-syndromic mitral valve prolapse.Semantic proximity Read ↗

The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve DegenerationSemantic proximity Read ↗

Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapseSemantic proximity Read ↗

Chemokine (C-C Motif) Ligand 2 Expressing Adventitial Fibroblast Expansion During Loeys-Dietz Syndrome Aortic Aneurysm Formation.Semantic proximity Read ↗

Macrophage lineages in heart valve development and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.