Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

18 Mar 2019

Abstract excerpt

OBJECTIVE: Genome wide association studies (GWAS) for type 2 diabetes (T2D) have identified genetic loci that often localise in non-coding regions of the genome, suggesting gene regulation effects. We combined genetic and transcriptomic analysis from human islets obtained from brain-dead organ donors or surgical patients to detect expression quantitative trait loci (eQTLs) and shed light into the regulatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Associations and Epidemiology
Share to Pancreatic function and diabetes
Share to Renin-Angiotensin System Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30956117
DOI: 10.1016/j.molmet.2019.03.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetesPMID 30956117Read ↗

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetesSemantic proximity Read ↗

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetesSemantic proximity Read ↗

Influence of genetic variants on gene expression in human pancreatic islets – implications for type 2 diabetesSemantic proximity Read ↗

TIGER: The gene expression regulatory variation landscape of human pancreatic isletsSemantic proximity Read ↗

Genetic regulation of RNA splicing in human pancreatic isletsSemantic proximity Read ↗

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolismSemantic proximity Read ↗

Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cellsSemantic proximity Read ↗

TIGER: The gene expression regulatory variation landscape of human pancreatic islets.Semantic proximity Read ↗

Genetic regulation of RNA splicing in human pancreatic isletsSemantic proximity Read ↗

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 DiabetesSemantic proximity Read ↗

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.Semantic proximity Read ↗

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.