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Article

Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics.

Clinical and translational science - 1 Jul 2021

Vora Bianca, Brackman Deanna J, Zou Ling, Garcia-Cremades Maria, Sirota Marina, Savic Radojka M, Giacomini Kathleen M

Abstract excerpt

The missense variant, breast cancer resistance protein (BCRP) p.Q141K, which encodes a reduced function BCRP, has been linked to poor response to allopurinol. Using a multifaceted approach, we aimed to characterize the relationship(s) between BCRP p.Q141K, the pharmacokinetics (PK) and pharmacodynamics (PD) of oxypurinol (the active metabolite of allopurinol), and serum uric acid (SUA) levels. A prospective...

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Identifiers

PMID: 33931953
DOI: 10.1111/cts.12992
PMCID: PMC8301548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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