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Article

Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants.

Life science alliance - 1 Jan 2024

Selves Janick, de Castro E Gloria Helena, Brunac Anne-Cécile, Saffi Jenifer, Guimbaud Rosine, Brousset Pierre, Hoffmann Jean-Sébastien

Abstract excerpt

Germline pathogenic variants in the exonuclease domain of the replicative DNA polymerase Pol ε encoded by the POLE gene, predispose essentially to colorectal and endometrial tumors by inducing an ultramutator phenotype. It is still unclear whether all the POLE alterations influence similar strength tumorigenesis, immune microenvironment, and treatment response. In this review, we summarize the current...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37891003
DOI: 10.26508/lsa.202302290
PMCID: PMC10610022

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Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants.PMID 37891003Read ↗

The game-changing impact of POLE mutations in oncology—a review from a gynecologic oncology perspectiveSemantic proximity Read ↗

Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain.Semantic proximity Read ↗

DNA polymerase epsilon catalytic subunit (POLE) in cancer: Implications for tumor biology and therapeutic strategies - A comprehensive review.Semantic proximity Read ↗

Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to favorable survival of tumors with POLE mutations outside the exonuclease domainSemantic proximity Read ↗

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.Semantic proximity Read ↗

Phenotypic POLE Variant Classification Identifies Patients Who May Have Favorable Prognosis and Benefit from Immunotherapy.Semantic proximity Read ↗

Interpretation of somatic POLE mutations in endometrial carcinoma.Semantic proximity Read ↗

Phenotype of POLE-mutated endometrial cancerSemantic proximity Read ↗

POLE mutations in endometrial carcinoma: Clinical and genomic landscape from a large prospective single‐center cohortSemantic proximity Read ↗

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancerSemantic proximity Read ↗

DNA polymerase ε and its roles in genome stabilitySemantic proximity Read ↗

Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study.Semantic proximity Read ↗

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