Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

21 Mar 2019

Abstract excerpt

BACKGROUND: Alzheimer's disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer's disease have been unable to distinguish between DNA methylation and DNA hydroxymethylation. DNA hydroxymethylation has been shown to be enriched in the human brain, although its role in Alzheimer's disease has not yet been fully...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Epigenetics and DNA Methylation
Share to Genomics and Rare Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30898171
DOI: 10.1186/s13148-019-0636-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s diseasePMID 30898171Read ↗

Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regionsSemantic proximity Read ↗

5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity.Semantic proximity Read ↗

A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortexSemantic proximity Read ↗

Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brainSemantic proximity Read ↗

Advances in epigenetics and epigenomics for neurodegenerative diseases.Semantic proximity Read ↗

Fine‐mapping and replication of EWAS loci harboring putative epigenetic alterations associated with AD neuropathology in a large collection of human brain tissue samplesSemantic proximity Read ↗

Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and bloodSemantic proximity Read ↗

Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer’s disease neuropathologySemantic proximity Read ↗

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s diseaseSemantic proximity Read ↗

Early epigenetic changes of Alzheimer’s disease in the human hippocampusSemantic proximity Read ↗

Early oligodendrocyte dysfunction signature in Alzheimer’s disease: Insights from DNA methylomics and transcriptomicsSemantic proximity Read ↗

Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer’s disease neuropathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.