Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.

doi:10.1016/j.cell.2012.08.029

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Article

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.

Cell - 14 Sept 2012

Imielinski Marcin, Berger Alice H, Hammerman Peter S, Hernandez Bryan, Pugh Trevor J, Hodis Eran, Cho Jeonghee, Suh James, Capelletti Marzia, Sivachenko Andrey, Sougnez Carrie, Auclair Daniel, Lawrence Michael S, Stojanov Petar, Cibulskis Kristian, Choi Kyusam, de Waal Luc, Sharifnia Tanaz, Brooks Angela, Greulich Heidi, Banerji Shantanu, Zander Thomas, Seidel Danila, Leenders Frauke, Ansén Sascha, Ludwig Corinna, Engel-Riedel Walburga, Stoelben Erich, Wolf Jürgen, Goparju Chandra, Thompson Kristin, Winckler Wendy, Kwiatkowski David, Johnson Bruce E, Jänne Pasi A, Miller Vincent A, Pao William, Travis William D, Pass Harvey I, Gabriel Stacey B, Lander Eric S, Thomas Roman K, Garraway Levi A, Getz Gad, Meyerson Matthew

Abstract excerpt

Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, is responsible for more than 500,000 deaths per year worldwide. Here, we report exome and genome sequences of 183 lung adenocarcinoma tumor/normal DNA pairs. These analyses revealed a mean exonic somatic mutation rate of 12.0 events/megabase and identified the majority of genes previously reported as significantly mutated in lung...

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PMID: 22980975
DOI: 10.1016/j.cell.2012.08.029
PMCID: PMC3557932

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