Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.

doi:10.1016/j.cell.2012.08.029

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Article

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.

Cell - 14 Sept 2012

Imielinski Marcin, Berger Alice H, Hammerman Peter S, Hernandez Bryan, Pugh Trevor J, Hodis Eran, Cho Jeonghee, Suh James, Capelletti Marzia, Sivachenko Andrey, Sougnez Carrie, Auclair Daniel, Lawrence Michael S, Stojanov Petar, Cibulskis Kristian, Choi Kyusam, de Waal Luc, Sharifnia Tanaz, Brooks Angela, Greulich Heidi, Banerji Shantanu, Zander Thomas, Seidel Danila, Leenders Frauke, Ansén Sascha, Ludwig Corinna, Engel-Riedel Walburga, Stoelben Erich, Wolf Jürgen, Goparju Chandra, Thompson Kristin, Winckler Wendy, Kwiatkowski David, Johnson Bruce E, Jänne Pasi A, Miller Vincent A, Pao William, Travis William D, Pass Harvey I, Gabriel Stacey B, Lander Eric S, Thomas Roman K, Garraway Levi A, Getz Gad, Meyerson Matthew

Abstract excerpt

Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, is responsible for more than 500,000 deaths per year worldwide. Here, we report exome and genome sequences of 183 lung adenocarcinoma tumor/normal DNA pairs. These analyses revealed a mean exonic somatic mutation rate of...

Topics

Adenocarcinoma
Adenocarcinoma of Lung
Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung
Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exome

Female

Genes, Neoplasm

Genome-Wide Association Study

High-Throughput Nucleotide Sequencing

Humans

Lung Neoplasms

Male

Middle Aged

Mutation

Mutation Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 22980975
DOI: 10.1016/j.cell.2012.08.029
PMCID: PMC3557932

Genes

EGFR
RBM10
SIK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-22980975-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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