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Article

Effect of age at puberty on risk of multiple sclerosis

21 Mar 2019

Abstract excerpt

Objective To investigate the potential for a causal effect of age at puberty on multiple sclerosis (MS) susceptibility using a mendelian randomization (MR) approach. Methods We used 372 genetic variants strongly associated with age at menarche in a genome-wide association study (GWAS) involving 329,245 women. The genetic architecture of pubertal timing across both sexes is highly correlated (genetic correlation...

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PMID: 30894442
DOI: 10.1212/wnl.0000000000007325

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