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Article

Adaptive and Innate Immunity Are Key Drivers of Age at Onset of Multiple Sclerosis

29 May 2024

Abstract excerpt

Background and Objectives: Multiple sclerosis (MS) age at onset (AAO) is a clinical predictor of long-term disease outcomes, independent of disease duration. Little is known about the genetic and biological mechanisms underlying age of first symptoms. We conducted a genome-wide association study (GWAS) to investigate associations between individual genetic variation and the MS AAO phenotype. Methods: single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38817245
DOI: 10.1212/nxg.0000000000200159

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