Article
Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.
Human molecular genetics - 15 Aug 2014
Cousminer Diana L, Stergiakouli Evangelia, Berry Diane J, Ang Wei, Groen-Blokhuis Maria M, Körner Antje, Siitonen Niina, Ntalla Ioanna, Marinelli Marcella, Perry John R B, Kettunen Johannes, Jansen Rick, Surakka Ida, Timpson Nicholas J, Ring Susan, Mcmahon George, Power Chris, Wang Carol, Kähönen Mika, Viikari Jorma, Lehtimäki Terho, Middeldorp Christel M, Hulshoff Pol Hilleke E, Neef Madlen, Weise Sebastian, Pahkala Katja, Niinikoski Harri, Zeggini Eleftheria, Panoutsopoulou Kalliope, Bustamante Mariona, Penninx Brenda W J H, Murabito Joanne, Torrent Maties, Dedoussis George V, Kiess Wieland, Boomsma Dorret I, Pennell Craig E, Raitakari Olli T, Hyppönen Elina, Davey Smith George, Ripatti Samuli, McCarthy Mark I, Widén Elisabeth
Abstract excerpt
Little is known about genes regulating male puberty. Further, while many identified pubertal timing variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to pubertal initiation or tempo. To address these questions, we performed genome-wide association meta-analysis in over 11 000 European samples with data on early pubertal...
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