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Article

Timing of Pubertal Development and Midlife Blood Pressure in Men and Women: A Mendelian Randomization Study.

The Journal of clinical endocrinology and metabolism - 1 Jan 2022

Chan Io Ieong, Kwok Man Ki, Schooling C Mary

Abstract excerpt

INTRODUCTION: Observational studies suggest earlier puberty is associated with higher adulthood blood pressure (BP), but these findings have not been replicated using Mendelian randomization (MR). We examined this question sex-specifically using larger genome-wide association studies (GWAS) with more extensive measures of pubertal timing. METHODS: We obtained genetic instruments proxying pubertal maturation (age...

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PMID: 34343299
DOI: 10.1210/clinem/dgab561

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