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Article

Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study.

PLoS medicine - 1 Aug 2018

Bell Joshua A, Carslake David, Wade Kaitlin H, Richmond Rebecca C, Langdon Ryan J, Vincent Emma E, Holmes Michael V, Timpson Nicholas J, Davey Smith George

Abstract excerpt

BACKGROUND: Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and cardiometabolic traits independent of childhood adiposity. METHODS AND FINDINGS: One-sample Mendelian randomisation (MR) analyses were conducted on up to 3,611 white-European female and male offspring from the Avon Longitudinal Study of Parents and...

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Identifiers

PMID: 30153260
DOI: 10.1371/journal.pmed.1002641
PMCID: PMC6112630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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