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Article

Estimation of Causal Effect of Age at Menarche on Pubertal Height Growth Using Mendelian Randomization.

Genes - 17 Apr 2022

Jo Eun Jae, Han Shizhong, Wang Kai

Abstract excerpt

We use Mendelian randomization to estimate the causal effect of age at menarche on late pubertal height growth and total pubertal height growth. The instrument SNPs selected from the exposure genome-wide association study (GWAS) are validated in additional population-matched exposure GWASs. Based on the inverse variance weighting method, there is a positive causal relationship of age at menarche on late pubertal...

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Causality
Genome-Wide Association Study
Menarche
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35456516
DOI: 10.3390/genes13040710
PMCID: PMC9029282

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