Article
Childhood obesity and multiple sclerosis: A Mendelian randomization study.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 2021
Harroud Adil, Mitchell Ruth E, Richardson Tom G, Morris John A, Forgetta Vincenzo, Davey Smith George, Baranzini Sergio E, Richards J Brent
Abstract excerpt
BACKGROUND: Higher childhood body mass index (BMI) has been associated with an increased risk of multiple sclerosis (MS). OBJECTIVE: To evaluate whether childhood BMI has a causal influence on MS, and whether this putative effect is independent from early adult obesity and pubertal timing. METHODS: We performed Mendelian randomization (MR) using summary genetic data on 14,802 MS cases and 26,703 controls....
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