Article
Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2018
Cousminer Diana L, Mitchell Jonathan A, Chesi Alessandra, Roy Sani M, Kalkwarf Heidi J, Lappe Joan M, Gilsanz Vicente, Oberfield Sharon E, Shepherd John A, Kelly Andrea, McCormack Shana E, Voight Benjamin F, Zemel Babette S, Grant Struan Fa
Abstract excerpt
Later puberty associates with lower areal bone mineral density (aBMD), and both are risk factors for osteoporosis. However, the association between puberty timing-associated genetic variants and aBMD during development, and the causal relationship between puberty timing and aBMD, remain uncharacterized. We constructed sex-specific polygenic risk scores (GRS) consisting of 333 genetic variants associated with...
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